Mechanisms involved in the developmental programming of adulthood disease

MJ Warner, SE Ozanne - Biochemical Journal, 2010 - portlandpress.com
There are many instances in life when the environment plays a critical role in the health
outcomes of an individual, yet none more so than those experienced in fetal and neonatal …

Resveratrol: its biologic targets and functional activity

S Pervaiz, AL Holme - Antioxidants & redox signaling, 2009 - liebertpub.com
Abstract 2852 The polyphenolic phytoalexin resveratrol (RSV) and its analogues have
received tremendous attention over the past couple of decades because of a number of …

Pathways linking the early environment to long-term health and lifespan

SK Barnes, SE Ozanne - Progress in biophysics and molecular biology, 2011 - Elsevier
The intrauterine environment is a major contributor to normal physiological growth and
development of an individual. Disturbances at this critical time can affect the long-term …

Maternity: neural mechanisms, motivational processes, and physiological adaptations.

M Numan, B Woodside - Behavioral neuroscience, 2010 - psycnet.apa.org
This review focuses on research on both the neural substrate of maternal responsiveness
and on the physiological, behavioral, and motivational adaptations to the maternal state. The …

Early-life nutritional programming of longevity

AM Vaiserman - Journal of developmental origins of health and …, 2014 - cambridge.org
Available data from both experimental and epidemiological studies suggest that inadequate
diet in early life can permanently change the structure and function of specific organs or …

Dietary protein mediates a trade‐off between larval survival and the development of male secondary sexual traits

AT Sentinella, AJ Crean, R Bonduriansky - Functional Ecology, 2013 - Wiley Online Library
Increased protein intake by adults typically enhances reproduction and shortens life, but
much less is known about the effects of protein intake prior to reproductive maturity. In …

Calorie restriction-regulated molecular pathways and its impact on various age groups: an overview

A Rachakatla, RR Kalashikam - DNA and Cell Biology, 2022 - liebertpub.com
Calorie restriction (CR) if planned properly with regular exercise at different ages can result
in healthy weight loss. CR can also have different beneficial effects on improving lifespan …

Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction

KKS Bhasin, A van Nas, LJ Martin, RC Davis… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE—We have examined maternal mechanisms for adult-onset glucose intolerance,
increased adiposity, and atherosclerosis using two mouse models for intrauterine growth …

Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species

AM Vaiserman, AK Koliada, RL Jirtle - Epigenetics & Chromatin, 2017 - Springer
Accumulating animal and human data indicate that environmental exposures experienced
during sensitive developmental periods may strongly influence risk of adult disease …

Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice

JH Chen, MS Martin-Gronert, J Tarry-Adkins… - PloS one, 2009 - journals.plos.org
We previously reported that maternal protein restriction in rodents influenced the rate of
growth in early life and ultimately affected longevity. Low birth weight caused by maternal …