Latent tuberculosis infection (LTBI) is a subclinical mycobacterial infection defined on the
basis of cellular immune response to mycobacterial antigens. The tuberculin skin test (TST) …

Millions of cases of tuberculosis (TB) go undiagnosed each year. Better diagnostic tools are
urgently needed. Biomarker-based or multiple marker biosignature-based tests, ideally …

The introduction and broad use of new immunosuppressive agents, including biologic
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …

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Tuberculosis (TB) still poses a major threat to mankind and during the last thirty years we
have seen a recrudescence of the disease even in countries where TB was thought to be …

Rationale: In the absence of active tuberculosis, a positive tuberculin skin test (TST) or
interferon-γ release assay (IGRA) result defines latent infection with Mycobacterium …

Background Given the current lack of effective vaccines against TB, the accuracy of
screening tests for determining or excluding latent TB infection (LTBI) is decisive in effective …

Background Prophylactic treatment of individuals with latent Mycobacterium tuberculosis
infection is an essential component of tuberculosis control in some settings. In China, the …

Objective: To determine whether interferon-gamma release assays (IGRAs) improve the
identification of HIV-infected individuals who could benefit from latent tuberculosis infection …

Biomarkers are indispensable to the development of new tuberculosis therapeutics and
vaccines. The most robust biomarkers measure factors that are essential to the underlying …