The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

Syndecans are a small family of four transmembrane proteoglycans in mammals. They have
similar structural organization, consisting of an N‐terminal ectodomain, single …

Background Inflammatory breast cancer (IBC), a particularly aggressive form of breast
cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted …

The expression of proteoglycans (PGs), essential macromolecules of the tumor
microenvironment, is markedly altered during malignant transformation and tumor …

In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly …

Survival and recurrence rates in breast cancer are variable for common diagnoses, and
therefore the biological underpinnings of the disease that determine those outcomes are yet …

Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …

Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …

Abstract microRNAs are small endogenous noncoding RNAs, which post‐transcriptionally
regulate gene expression. In breast cancer, overexpression of the transmembrane heparan …

The heparan sulfate proteoglycan syndecan-1 (Sdc1) modulates cell proliferation, adhesion,
migration and angiogenesis. Proteinase-mediated shedding converts Sdc1 from a …