The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

The adult mammalian heart is non-regenerative owing to the post-mitotic nature of
cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of …

Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited
by the time required to generate stable mutant lines. We describe a system for gene …

Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …

How diverse cell fates and complex forms emerge and feed back to each other to sculpt
functional organs remains unclear. In the developing heart, the myocardium transitions from …

The goal of replenishing the cardiomyocyte (CM) population using regenerative therapies
following myocardial infarction (MI) is hampered by the limited regeneration capacity of adult …

Heart failure causes significant morbidity and mortality worldwide. The understanding of
heart failure pathomechanisms and options for treatment remain incomplete. Zebrafish has …

Atrial fibrillation (AF), the most common arrhythmia, is a growing epidemic with substantial
morbidity and economic burden. Mechanisms underlying vulnerability to AF remain poorly …

Zebrafish are a relevant and useful vertebrate model species to study normal-and patho-
physiology, including that of the heart, due to conservation of protein-coding genes, organ …