Protein corona: a new approach for nanomedicine design

VH Nguyen, BJ Lee - International journal of nanomedicine, 2017 - Taylor & Francis
After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is
formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Single-cell force spectroscopy, an emerging tool to quantify cell adhesion to biomaterials

AV Taubenberger, DW Hutmacher… - Tissue Engineering Part …, 2014 - liebertpub.com
Cell adhesion receptors play a central role in sensing and integrating signals provided by
the cellular environment. Thus, understanding adhesive interactions at the cell–biomaterial …

Controllable environment protein corona-disguised immunomagnetic beads for high-performance circulating tumor cell enrichment

X Zhou, Y Zhang, K Kang, Y Mao, Y Yu, Q Yi… - Analytical …, 2022 - ACS Publications
The enrichment performance of immunomagnetic beads (IMBs) in blood samples is usually
challenging due to the ungoverned, in situ-formed protein corona, as it generally leads to …

Fibrinogen matrix deposited on the surface of biomaterials acts as a natural anti-adhesive coating

R Safiullin, W Christenson, H Owaynat, IS Yermolenko… - Biomaterials, 2015 - Elsevier
Adsorption of fibrinogen on the luminal surface of biomaterials is a critical early event during
the interaction of blood with implanted vascular graft prostheses which determines their …

Quantitative analysis of protein corona on precoated protein nanoparticles and determined nanoparticles with ultralow protein corona and efficient targeting in vivo

Z Zhong, S Fang, Y Li, Y Huang, Y Zhang… - … Applied Materials & …, 2021 - ACS Publications
The protein corona on nanoparticles (NPs) is a critical problem that often screens the
targeting molecules and becomes one of the key reasons for the lack of practical application …

Quantified forces between HepG2 hepatocarcinoma and WA07 pluripotent stem cells with natural biomaterials correlate with in vitro cell behavior

R Harjumäki, RWN Nugroho, X Zhang, YR Lou… - Scientific reports, 2019 - nature.com
In vitro cell culture or tissue models that mimic in vivo cellular response have potential in
tissue engineering and regenerative medicine, and are a more economical and accurate …

Fibrinogen: a journey into biotechnology

A Bratek-Skicki, P Żeliszewska, JM Ruso - Soft Matter, 2016 - pubs.rsc.org
Fibrinogen has been known since the mid-nineteenth century. Although initially its interest
had been within the field of physiology over time its study has spread to new disciplines …

Molecular dynamics simulations of the initial adsorption stages of fibrinogen on mica and graphite surfaces

S Köhler, F Schmid, G Settanni - Langmuir, 2015 - ACS Publications
Fibrinogen, a blood glycoprotein of vertebrates, plays an essential role in blood clotting by
polymerizing into fibrin when activated. Upon adsorption on material surfaces, it also …

Thermo-sensitive amylase-starch double-layer polymer nanoparticles with self-polishing and protein corona-free property for drug delivery applications

H Chen, D Ye, Y Huang, X Luo, X Wu, J Zhang… - International Journal of …, 2023 - Elsevier
Protein corona formation can lead to obstructive screening of targeting groups of
nanoparticles (NPs). Also, the targeting groups are subjected to physiochemical interactions …