Beneficial role of phytochemicals on oxidative stress and age‐related diseases

C Forni, F Facchiano, M Bartoli… - BioMed research …, 2019 - Wiley Online Library
Aging is related to a number of functional and morphological changes leading to
progressive decline of the biological functions of an organism. Reactive Oxygen Species …

Influence of resveratrol on the immune response

L Malaguarnera - Nutrients, 2019 - mdpi.com
Resveratrol is the most well-known polyphenolic stilbenoid, present in grapes, mulberries,
peanuts, rhubarb, and in several other plants. Resveratrol can play a beneficial role in the …

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

W Liu, Y Rong, J Wang, Z Zhou, X Ge, C Ji… - Journal of …, 2020 - Springer
Background Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with
high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano …

[HTML][HTML] The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy

C Grinán-Ferré, A Bellver-Sanchis, V Izquierdo… - Ageing Research …, 2021 - Elsevier
While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

SIRT1 activation by natural phytochemicals: an overview

C Iside, M Scafuro, A Nebbioso, L Altucci - Frontiers in pharmacology, 2020 - frontiersin.org
Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …

A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice

W Zhu, Y Dong, P Xu, Q Pan, K Jia, P Jin, M Zhou… - Acta Biomaterialia, 2022 - Elsevier
Diabetic wounds are difficult to heal because of persistent inflammation and limited
angiogenesis. Resveratrol (RES) is an anti-inflammatory and antioxidant agent. Platelet …

Polyphenols and neuroprotection: Therapeutic implications for cognitive decline

G Caruso, SA Torrisi, MP Mogavero, W Currenti… - Pharmacology & …, 2022 - Elsevier
Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …

Neuroprotective mechanisms of resveratrol in Alzheimer's disease: role of SIRT1

BAQ Gomes, JPB Silva, CFR Romeiro… - Oxidative medicine …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive and neurodegenerative disorder of the cortex and
hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD …

Polyphenols from food and natural products: Neuroprotection and safety

RFM Silva, L Pogačnik - Antioxidants, 2020 - mdpi.com
Polyphenols are naturally occurring micronutrients that are present in many food sources.
Besides being potent antioxidants, these molecules may also possess anti-inflammatory …

[HTML][HTML] The PI3K/Akt signaling axis in Alzheimer's disease: a valuable target to stimulate or suppress?

E Razani, A Pourbagheri-Sigaroodi… - Cell Stress and …, 2021 - Elsevier
Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …