Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …

Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …

Distinct subcellular pH levels, especially in lysosomes and endosomes, are essential for the
degradation, modification, sorting, accumulation, and secretion of macromolecules. Here …

Although cancer is characterized by an intratumoral genetic heterogeneity, a totally
deranged pH control is a common feature of most cancer histotypes. Major determinants of …

WNKs are serine/threonine kinases that comprise a unique branch of the kinome. They are
so-named owing to the unusual placement of an essential catalytic lysine. WNKs have now …

Manipulation of the extracellular and/or intracellular pH of tumors may have considerable
potential in cancer therapy. The extracellular space of most tumors is mildly acidic, owing to …

Cancer cells generate large quantities of cytoplasmic protons as byproducts of aberrantly
activated aerobic glycolysis and lactate fermentation. To avoid potentially detrimental …

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Introduction: Cancer is an intricate disorder/dysfunction of cells that can be defined as a …

Acidity is one of the main features of the tumors. The V-ATPase is the primary responsible for
the control of tumor microenvironment by proton extrusion to the extracellular medium. The …

Multidrug resistance (MDR) is the resistance of cells toward various drugs commonly used in
tumor treatment. The mechanism of drug resistance in oral cancer is not completely …