The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
Human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a
perfect paradigm of the functional complexity of a biological macromolecule. First, it plays a …
perfect paradigm of the functional complexity of a biological macromolecule. First, it plays a …
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
F Shah, D Logsdon, RA Messmann… - NPJ precision …, 2017 - nature.com
Abstract Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …
APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 …
D Wang, DB Xiang, X Yang, LS Chen, MX Li, ZY Zhong… - Lung cancer, 2009 - Elsevier
PURPOSE: Apurinic/apyrimidinic endonuclease (APE1), a bifunctional AP
endonuclease/redox factor, is important in DNA repair and redox signaling, may be …
endonuclease/redox factor, is important in DNA repair and redox signaling, may be …
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer
MR Kelley, L Cheng, R Foster, R Tritt, J Jiang… - Clinical Cancer …, 2001 - AACR
The DNA base excision repair pathway is responsible for the repair of cellular alkylation and
oxidative DNA damage. A crucial step in the BER pathway involves the cleavage of …
oxidative DNA damage. A crucial step in the BER pathway involves the cleavage of …
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential …
Abstract Apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) is a
multifunctional protein involved in DNA base excision repair and redox regulation of many …
multifunctional protein involved in DNA base excision repair and redox regulation of many …
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
The apurinic endonuclease 1/redox factor-1 (APE1) has a crucial function in DNA repair and
in redox signaling in mammals, and recent studies identify it as an excellent target for …
in redox signaling in mammals, and recent studies identify it as an excellent target for …
Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells
▪ Abstract Cells in multicellular organisms are exposed to both endogenous oxidative
stresses generated metabolically and to oxidative stresses that originate from neighboring …
stresses generated metabolically and to oxidative stresses that originate from neighboring …
Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons
Y Jiang, C Guo, MR Vasko, MR Kelley - Cancer research, 2008 - AACR
Peripheral neuropathy is one of the major side effects of the anticancer drug cisplatin.
Although previous work suggests that this neuropathy correlates with formation of DNA …
Although previous work suggests that this neuropathy correlates with formation of DNA …
Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection
H Masutani, J Bai, YC Kim, J Yodoi - Molecular neurobiology, 2004 - Springer
Oxidative stress has been implicated in the pathogenesis of a wide variety of neuronal
diseases, including ischemic neuronal injury, Alzheimer's disease, and Parkinson's disease …
diseases, including ischemic neuronal injury, Alzheimer's disease, and Parkinson's disease …
Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells
J Bai, H Nakamura, YW Kwon, I Hattori… - Journal of …, 2003 - Soc Neuroscience
Thioredoxin (TRX) has a role in a variety of biological processes, including cytoprotection
and the activation of transcription factors. Nerve growth factor (NGF) is a major survival factor …
and the activation of transcription factors. Nerve growth factor (NGF) is a major survival factor …