Background: The test-negative design is an increasingly popular approach for estimating
vaccine effectiveness (VE) due to its efficiency. This review aims to examine published test …

The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Background Live attenuated influenza vaccines have been shown to significantly reduce
influenza in diverse populations of children, but no efficacy studies have been done in …

Background The clinical effectiveness of monovalent influenza A (H1N1) pdm09 vaccines
has not been comprehensively summarised. We undertook a systematic review and meta …

Influenza is a viral infection that affects much of the global population each year. Vaccination
remains the most effective tool for preventing the disease. Live attenuated influenza vaccine …

Live attenuated influenza vaccines (LAIVs) are believed to be immunologically superior to
inactivated influenza vaccines, because they can induce a variety of adaptive immune …

Influenza is a highly contagious respiratory infection caused by the circulating Swine flu
virus. According to the World Health Organization (WHO), the unique blending strain of …

Abstract Background We evaluated a Russian-backbone, live, attenuated influenza vaccine
(LAIV) for immunogenicity and viral shedding in a randomized, placebo-controlled trial …

Live attenuated, cold-adapted influenza vaccines exhibit several desirable characteristics,
including the induction of systemic, mucosal, and cell-mediated immunity resulting in …

Introduction: Live attenuated influenza vaccines (LAIVs) have been in use for more than
three decades and are now licensed in many countries. There is evidence that LAIVs can …