Esophageal cancer (EC) is a common gastrointestinal malignancy with poor prognosis and
high mortality. Although combined therapeutic strategies have been developed, the 5-year …

The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …

Background Emerging evidence has demonstrated that RNA-binding protein dysregulation
is involved in esophageal squamous cell carcinoma (ESCC) progression. However, the role …

The tumor microenvironment comprises multiple cell types, like cancer cells, endothelial
cells, fibroblasts, and immune cells. In recent years, there have been massive research …

MDSCs (myeloid-derived suppressor cells) are crucial for immune system evasion in cancer.
They accumulate in peripheral blood and tumor microenvironment, suppressing immune …

The average five-year survival rate for esophageal cancer, a common malignant tumor of the
digestive system, is barely 20%. The majority of esophageal squamous cell carcinoma …

Chemokine receptors are significantly expressed in the surface of most inflammatory cells
and tumor cells. Guided by chemokines, inflammatory cells which express the relevant …

The prognosis of esophageal cancer (ESCA) is very poor, with a 5‐year survival rate of less
than 20%. On the other hand, inflammation is the characteristic hallmark of ESCA; however …

The tumor microenvironment (TME) comprises all non-tumor elements of cancer and
strongly influences disease progression and phenotype. To understand tumor biology and …

The depth of invasion plays a critical role in predicting the prognosis of early esophageal
cancer, but the reasons behind invasion and the changes occurring in invasive areas are …