Metal Complexes in cancer treatment: Journey so far

A Kumar Singh, A Kumar, H Singh… - Chemistry & …, 2023 - Wiley Online Library
Metal complexes in cancer therapy have attracted much interest mainly because metals
exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and …

The challenging treatment of cisplatin-resistant tumors: State of the art and future perspectives

G Coffetti, M Moraschi, G Facchetti, I Rimoldi - Molecules, 2023 - mdpi.com
One of the main problems in chemotherapy using platinum drugs as anticancer agents is the
resistance phenomenon. Synthesizing and evaluating valid alternative compounds is …

Potent platinum (iv) prodrugs that incorporate a biotin moiety to selectively target cancer cells

A Khoury, JA Sakoff, J Gilbert, S Karan, CP Gordon… - Pharmaceutics, 2022 - mdpi.com
Four platinum (IV) prodrugs incorporating a biotin moiety to selectively target cancer cells
were synthesised, characterised, and their biological activity assessed. All complexes …

Bioactive platinum (iv) complexes incorporating halogenated phenylacetates

AD Aputen, MG Elias, J Gilbert, JA Sakoff, CP Gordon… - Molecules, 2022 - mdpi.com
A new series of cytotoxic platinum (IV) complexes (1–8) incorporating halogenated
phenylacetic acid derivatives (4-chlorophenylacetic acid, 4-fluorophenylacetic acid, 4 …

[HTML][HTML] Chemotherapeutic potential of Chlorambucil-Platinum (IV) Prodrugs against Cisplatin-resistant colorectal Cancer cells

MG Elias, AD Aputen, S Fatima, TJ Mann… - International Journal of …, 2024 - mdpi.com
Chlorambucil-platinum (IV) prodrugs exhibit multi-mechanistic chemotherapeutic activity
with promising anticancer potential. The platinum (II) precursors of the prodrugs have been …

Combination of chlorambucil and mercaptopurine show effective anti-cancer effects in mice model

W Xu, Y Di, S Chu, Z Wang, H Long, L Pu… - International Journal …, 2024 - Taylor & Francis
Background Combination therapy employing multiple drugs has been shown to enhance the
efficacy of cancer treatment. Chlorambucil (Chl) and 6-mercaptopurine (6MP) are the first …

Anticancer Effect of PtIIPHENSS, PtII5MESS, PtII56MESS and their Platinum (IV)-dihydroxy derivatives Against Triple-Negative Breast Cancer and Cisplatin-Resistant …

MG Elias, S Fatima, TJ Mann, S Karan, M Mikhael… - …, 2024 - pmc.ncbi.nlm.nih.gov
Simple Summary Conventional intravenous platinum (II) chemotherapy medications,
including carboplatin, oxaliplatin and cisplatin, have demonstrated remarkable efficacy in …

Versatile platinum (iv) prodrugs of naproxen and acemetacin as chemo-anti-inflammatory agents

AD Aputen, MG Elias, J Gilbert, JA Sakoff, CP Gordon… - Cancers, 2023 - mdpi.com
Simple Summary Traditional intravenous platinum (II) chemotherapy drugs such as cisplatin,
oxaliplatin and carboplatin are highly effective in treating multiple cancer types …

Cytotoxic Pt (ii) complexes containing alizarin: a selective carrier for DNA metalation

R Caligiuri, L Massai, A Geri, L Ricciardi… - Dalton …, 2024 - pubs.rsc.org
Many efforts have been made in the last few decades to selectively transport antitumor
agents to their potential target sites with the aim to improve efficacy and selectivity. Indeed …

Platinum (IV) Prodrugs Incorporating an Indole-Based Derivative, 5-Benzyloxyindole-3-Acetic Acid in the Axial Position Exhibit Prominent Anticancer Activity

AD Aputen, MG Elias, J Gilbert, JA Sakoff… - International journal of …, 2024 - mdpi.com
Kinetically inert platinum (IV) complexes are a chemical strategy to overcome the
impediments of standard platinum (II) antineoplastic drugs like cisplatin, oxaliplatin and …