Thrombotic complications in patients with COVID-19: pathophysiological mechanisms, diagnosis, and treatment

A Gąsecka, JA Borovac, RA Guerreiro… - … drugs and therapy, 2021 - Springer
Introduction Emerging evidence points to an association between severe clinical
presentation of COVID-19 and increased risk of thromboembolism. One-third of patients …

Coagulation and fibrinolysis in diabetes

SH Alzahrani, RA Ajjan - Diabetes and Vascular Disease …, 2010 - journals.sagepub.com
Atherothrombotic complications are the main cause of mortality in subjects with diabetes.
Premature atherosclerosis, increased platelet reactivity and activation of coagulation factors …

Thrombosis and vascular inflammation in diabetes: mechanisms and potential therapeutic targets

N Pechlivani, RA Ajjan - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Cardiovascular disease remains the main cause of morbidity and mortality in patients with
diabetes. The risk of vascular ischemia is increased in this population and outcome …

Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity

RA Ajjan, T Gamlen, KF Standeven… - Blood, The Journal …, 2013 - ashpublications.org
Diabetes is associated with hypofibrinolysis by mechanisms that are only partially
understood. We investigated the effects of in vivo plasminogen glycation on fibrinolysis …

Thiazolidinediones as anti‐inflammatory and anti‐atherogenic agents

A Ceriello - Diabetes/metabolism research and reviews, 2008 - Wiley Online Library
In the last few years, there has been increasing focus on the impact of interventions on
cardiovascular outcomes in patients with type 2 diabetes. Insulin resistance and …

Diabetes and cardiovascular disease: pathophysiology of a life-threatening epidemic

RJ King, PJ Grant - Herz, 2016 - search.proquest.com
Diabetes is associated with the development of premature cardiovascular disease (CVD),
which relates to the clustering of risk factors such as dyslipidaemia, hypertension, obesity …

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin (ogen)

DB Kell, E Pretorius - Integrative Biology, 2015 - academic.oup.com
Although the two phenomena are usually studied separately, we summarise a considerable
body of literature to the effect that a great many diseases involve (or are accompanied by) …

Molecular diversity of anticoagulants from haematophagous animals

CY Koh, RM Kini - Thrombosis and Haemostasis, 2009 - thieme-connect.com
To obtain blood meals, haematophagous animals are armed with potent pharmacological
molecules to overcome several of their hosts' response systems. Among them, a large …

Aspirin: pharmacology and clinical applications

EV Paez Espinosa, JP Murad, FT Khasawneh - Thrombosis, 2012 - Wiley Online Library
Antiplatelet therapy has been documented to reduce risks of cardiovascular disease after
acute myocardial infarction, coronary artery bypass graft, and in chronic atrial fibrillation …

The cardiovascular effects of metformin: further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus

G Anfossi, I Russo, K Bonomo… - Current Vascular …, 2010 - ingentaconnect.com
Cardiovascular events occurring in type 2 diabetes (T2DM) are a major problem in clinical
practice. In particular, the risk of myocardial infarction (MI) presented by patients affected by …