Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

M Vallet-Regí, F Schüth, D Lozano, M Colilla… - Chemical Society …, 2022 - pubs.rsc.org
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …

[HTML][HTML] Mesoporous silica nanoparticles as carriers for therapeutic biomolecules

RR Castillo, D Lozano, M Vallet-Regí - Pharmaceutics, 2020 - mdpi.com
The enormous versatility of mesoporous silica nanoparticles permits the creation of a large
number of nanotherapeutic systems for the treatment of cancer and many other pathologies …

Nanoparticles to knockdown osteoporosis-related gene and promote osteogenic marker expression for osteoporosis treatment

P Mora-Raimundo, D Lozano, M Manzano… - ACS …, 2019 - ACS Publications
Osteoporosis is the most common disease involving bone degeneration. Current clinical
treatments are not able to offer a satisfying curative effect, so the development of effective …

Fabrication of novel Si-doped hydroxyapatite/gelatine scaffolds by rapid prototyping for drug delivery and bone regeneration

FJ Martínez-Vázquez, MV Cabañas, JL Paris… - Acta biomaterialia, 2015 - Elsevier
Porous 3-D scaffolds consisting of gelatine and Si-doped hydroxyapatite were fabricated at
room temperature by rapid prototyping. Microscopic characterization revealed a highly …

Local drug delivery for enhancing fracture healing in osteoporotic bone

L Kyllönen, M D'Este, M Alini, D Eglin - Acta biomaterialia, 2015 - Elsevier
Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis
and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an …

Preparation and the hemostatic property study of porous gelatin microspheres both in vitro and in vivo

L Li, Y Du, Z Yin, L Li, H Peng, H Zheng, A Yang… - Colloids and Surfaces B …, 2020 - Elsevier
Rapid hemostasis is crucial to saving the lives of traumatic patients in emergency medical
treatment. To improve the hemostatic performance of the gelatin microspheres (GMs) in vivo …

Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells

C Heras, S Sanchez-Salcedo, D Lozano, J Peña… - Acta biomaterialia, 2019 - Elsevier
There is an urgent need of biosynthetic bone grafts with enhanced osteogenic capacity. In
this study, we describe the design of hierarchical meso-macroporous 3D-scaffolds based on …

Porous gelatin microspheres for controlled drug delivery with high hemostatic efficacy

S Cao, L Li, Y Du, J Gan, J Wang, T Wang, Y Liu… - Colloids and Surfaces B …, 2021 - Elsevier
Effective hemostasis and antibacterial efficacy for extensive trauma in a warzone and civilian
accidents are important for reducing mortalities and serious complications. Gelatin has been …

[HTML][HTML] Design of 3d scaffolds for hard tissue engineering: From apatites to silicon mesoporous materials

A García, MV Cabañas, J Peña, S Sánchez-Salcedo - Pharmaceutics, 2021 - mdpi.com
Advanced bioceramics for bone regeneration constitutes one of the pivotal interests in the
multidisciplinary and far-sighted scientific trajectory of Prof. Vallet Regí. The different …

Osteogenic effect of ZnO-mesoporous glasses loaded with osteostatin

R Pérez, S Sanchez-Salcedo, D Lozano, C Heras… - Nanomaterials, 2018 - mdpi.com
Mesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for
their putative clinical use as scaffolds for bone regeneration. Their outstanding textural …