Background Drug-induced drug resistance in cancer has been attributed to diverse
biological mechanisms at the individual cell or cell population scale, relying on …

Background A thorough understanding of the ecological and evolutionary mechanisms that
drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer …

Growth of biological tissues has been recently treated within the framework of Continuum
Mechanics, by adopting heterogeneous poroelastic models where the interaction between …

Failure to understand evolutionary dynamics has been hypothesized as limiting our ability to
control biological systems. An increasing awareness of similarities between macroscopic …

Understanding intrinsic and acquired resistance is crucial to overcoming cancer
chemotherapy failure. While it is well-established that intratumor, subclonal genetic and …

Mutation is an unavoidable and indispensable phenomenon in both biological and social
systems undergoing evolution through replication-selection processes. Here we show that …

Mechanical stress accumulating during growth in solid tumors plays a crucial role in the
tumor mechanobiology. Stresses arise as a consequence of the spatially inhomogeneous …

Preventing relapse is the major challenge to effective therapy in cancer. Within the tumour,
stromal (ST) cells play an important role in cancer progression and the emergence of drug …

This paper is concerned with exploring the microscopic basis for the discrete versions of the
standard replicator equation and the adjusted replicator equation. To this end, we introduce …

The innovation of the biomedical engineering (BME) industry is inseparable from its
cooperation with medical institutions. China has considerable medical institutions. Although …