Objective Increasing evidence supports an association between midlife cardiovascular risk
factors (CVRFs) and risk of dementia, but less is known about whether CVRFs influence …

Over the last quarter century, a staggering number of brain imaging studies have probed the
neural basis of age-related cognitive decline. Using multimodal brain imaging tools, we now …

Lower midlife physical activity is associated with higher risk of neurodegenerative disease in
late life. However, it remains unknown whether physical exercise and fitness are associated …

Although late-life depression (LLD) is a serious health problem and more common than
dementia in people over 60, it is underdiagnosed and undertreated. The cognitive-emotional …

Background and Objectives To understand the role of premature (defined as≤ 60 years)
cardiovascular disease (CVD) in brain health earlier in life, we examined the associations of …

Aging results in less detailed memories, reflecting reduced fidelity of remembered compared
to real-world representations. We tested whether poorer representational fidelity across …

We aimed to examine the relationship between Apolipoprotein E ε4 (APOE* 4) carriage on
cognitive decline, and whether these associations were moderated by sex, baseline age …

We aimed to examine the white matter changes associated with lexical production
difficulties, beginning in midlife with increased naming latencies. To delay lexical production …

Visual short-term memory (vSTM) is a cognitive resource that declines with age. This study
investigated whether electroencephalography (EEG) correlates of vSTM vary with cognitive …

Healthy aging is associated with a heterogeneous decline across cognitive functions,
typically observed between language comprehension and language production (LP) …