Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease
affecting more than 30% of the population. Exposure to even minute quantities of allergens …

Critical quality attributes (CQA) are physical, chemical, biological or microbiological
properties or characteristics that must be within an appropriate limit, range or distribution to …

▪ Abstract Phagocytosis of pathogens by macrophages initiates the innate immune
response, which in turn orchestrates the adaptive response. In order to discriminate between …

The present invention concerns polypeptides comprising a variant Fc region. More
particularly, the present invention concerns Fc region-containing polypeptides that have …

Memory B cells formed in response to microbial antigens provide immunity to later
infections; however, the inability to detect rare endogenous antigen-specific cells limits …

At sites of vascular injury, platelets come into contact with subendothelial collagen, which
triggers their activation and the formation of a hemostatic plug. Besides glycoprotein Ib …

IgM antibodies constitute the major component of the natural antibodies and is also the first
class of antibodies produced during a primary antibody response. The IgM-type antibodies …

The present invention concerns polypeptides comprising a variant Fc region. More
particularly, the present invention concerns Fc region-containing polypeptides that have …

Immunoglobulins couple the recognition of invading pathogens with the triggering of potent
effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger …

Effective tumor immunity requires recognition of tumor cells coupled with the activation of
host effector responses. Fc receptor (FcR) γ−/− mice, which lack the activating FcγR types I …