Role of CFTR in epithelial physiology
V Saint-Criq, MA Gray - Cellular and Molecular Life Sciences, 2017 - Springer
Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …
Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease
Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …
[HTML][HTML] Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis
Background & Aims Excessive consumption of ethanol is one of the most common causes of
acute and chronic pancreatitis. Alterations to the gene encoding the cystic fibrosis …
acute and chronic pancreatitis. Alterations to the gene encoding the cystic fibrosis …
Intracellular Ca2+ Signalling in the Pathogenesis of Acute Pancreatitis: Recent Advances and Translational Perspectives
Intracellular Ca2+ signalling is a major signal transductional pathway in non-excitable cells,
responsible for the regulation of a variety of physiological functions. In the secretory …
responsible for the regulation of a variety of physiological functions. In the secretory …
CFTR: a new horizon in the pathomechanism and treatment of pancreatitis
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that
conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations in the …
conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations in the …
Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas
Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in
secretory epithelial cells due to the defective ion flux across the cystic fibrosis …
secretory epithelial cells due to the defective ion flux across the cystic fibrosis …
The physiology and pathophysiology of pancreatic ductal secretion: the background for clinicians
The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These
exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most …
exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most …
Caspase‐9 acts as a regulator of necroptotic cell death
Necroptosis is a regulated necrotic‐like cell death modality which has come into the focus of
attention since it is known to contribute to the pathogenesis of many inflammatory and …
attention since it is known to contribute to the pathogenesis of many inflammatory and …
[HTML][HTML] Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion
Pancreatic exocrine secretory processes are challenging to investigate on primary epithelial
cells. Pancreatic organoid cultures may help to overcome shortcomings of the current …
cells. Pancreatic organoid cultures may help to overcome shortcomings of the current …
[HTML][HTML] Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation
H Xiang, F Guo, X Tao, Q Zhou, S Xia, D Deng, L Li… - Theranostics, 2021 - ncbi.nlm.nih.gov
Recent studies have proven that the overall pathophysiology of pancreatitis involves not
only the pancreatic acinar cells but also duct cells, however, pancreatic duct contribution in …
only the pancreatic acinar cells but also duct cells, however, pancreatic duct contribution in …