CAR T cell therapy: a versatile living drug

RC De Marco, HJ Monzo, PM Ojala - International Journal of Molecular …, 2023 - mdpi.com
After seeing a dramatic increase in the development and use of immunotherapy and
precision medicine over the past few decades, oncological care now embraces the start of …

CAR‐T cell therapy in hematological malignancies: Where are we now and where are we heading for?

AN Khan, S Asija, J Pendhari… - European Journal of …, 2024 - Wiley Online Library
Chimeric antigen receptor T (CAR‐T) therapy has emerged as a revolutionary new pillar in
cancer care, particularly in relapsed/refractory (r/r) B‐cell malignancies. Following …

[HTML][HTML] Mechanisms of resistance and treatment of relapse after CAR T-cell therapy for large B-cell lymphoma and multiple myeloma

K Rejeski, MD Jain, EL Smith - Transplantation and Cellular Therapy, 2023 - Elsevier
Although chimeric antigen receptor (CAR) T cell therapy (CAR-T) has altered the treatment
landscape for relapsed/refractory B cell malignancies and multiple myeloma, only a minority …

Progress on phage display technology: tailoring antibodies for cancer immunotherapy

RKA França, IC Studart, MRL Bezerra, LQ Pontes… - Viruses, 2023 - mdpi.com
The search for innovative anti-cancer drugs remains a challenge. Over the past three
decades, antibodies have emerged as an essential asset in successful cancer therapy. The …

[HTML][HTML] The paths and challenges of “off-the-shelf” CAR-T cell therapy: An overview of clinical trials

V Moradi, A Omidkhoda, N Ahmadbeigi - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The advent of chimeric antigen receptor T cells (CAR-T cells) has made a tremendous
revolution in the era of cancer immunotherapy, so that since 2017 eight CAR-T cell products …

CAR T‐cell therapy for multiple myeloma: a clinical practice‐oriented review

NL Sadek, BA Costa, K Nath… - Clinical Pharmacology …, 2023 - Wiley Online Library
The emergence of chimeric antigen receptor (CAR) T‐cell therapy has revolutionized the
treatment of hematologic malignancies, including multiple myeloma (MM). Two BCMA …

Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

P Celichowski, M Turi, S Charvátová… - Journal of Translational …, 2023 - Springer
Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful
personalized therapeutic agents showing dramatic preclinical and clinical results …

[HTML][HTML] The dilemmas and possible solutions for CAR-T cell therapy application in solid tumors

L Wang, L Zhang, LC Dunmall, YY Wang, Z Fan… - Cancer Letters, 2024 - Elsevier
Chimeric antigen receptor T (CAR-T) cell therapy, as an adoptive immunotherapy, is playing
an increasingly important role in the treatment of malignant tumors. CAR-T cells are referred …

Immunotherapies inducing immunogenic cell death in cancer: insight of the innate immune system

KM Calvillo-Rodríguez, HY Lorenzo-Anota… - Frontiers in …, 2023 - frontiersin.org
Cancer immunotherapies include monoclonal antibodies, cytokines, oncolytic viruses,
cellular therapies, and other biological and synthetic immunomodulators. These are …

Effectiveness and safety of anti-BCMA chimeric antigen receptor T-cell treatment in relapsed/refractory multiple myeloma: a comprehensive review and meta-analysis …

D Hu, L Chen, D Yan, W Dong, M Chen… - Frontiers in …, 2023 - frontiersin.org
Background: Chimeric antigen receptor T cells treatment targeting B cell maturation antigen
(BCMA) is an emerging treatment option for relapsed/refractory multiple myeloma (RRMM) …