Stem cells can be defined as units of biological organization that are responsible for the
development and the regeneration of organ and tissue systems. They are able to renew their …

It is becoming increasingly evident that most cell types are capable of forming and releasing
multiple distinct classes of membrane-enclosed packages, referred to as extracellular …

Pluripotent stem cells have the ability to undergo self‐renewal and to give rise to all cells of
the tissues of the body. However, this definition has been recently complicated by the …

Tendon injuries are a common cause of physical disability. They present a clinical challenge
to orthopedic surgeons because injured tendons respond poorly to current treatments …

Oxidative stress results from an imbalance between reactive oxygen species (ROS)
production and antioxidant defense mechanisms. The regulation of stem cell self‐renewal …

The establishment of cartilage regenerative medicine is an important clinical issue, but the
search for cell sources able to restore cartilage integrity proves to be challenging. Human …

Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …

This review deals with the latest advances in the study of embryonic stem cells (ESC) and
induced pluripotent stem cells (iPSC) from domesticated species, with a focus on pigs, cattle …

Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study
conditions and diseases including those of the eye that lack appropriate animal models to …

Highlights•Human embryonic stem cell (hESC) can be derived from a single eight-cell
embryo blastomere.•hESC can be derived, expanded, and maintained in defined, xeno-free …