Validity of clinical severity scores for respiratory syncytial virus: a systematic review

Z Sheikh, E Potter, Y Li, RA Cohen… - The Journal of …, 2024 - academic.oup.com
Background Respiratory syncytial virus (RSV) is a widespread respiratory pathogen, and
RSV-related acute lower respiratory tract infections are the most common cause of …

Infection biomarkers based on metabolomics

R Araújo, LFN Bento, TAH Fonseca, CP Von Rekowski… - Metabolites, 2022 - mdpi.com
Current infection biomarkers are highly limited since they have low capability to predict
infection in the presence of confounding processes such as in non-infectious inflammatory …

The spectrum of clinical biomarkers in severe malaria and new avenues for exploration

LPK Foko, G Narang, S Tamang, J Hawadak, J Jakhan… - Virulence, 2022 - Taylor & Francis
Globally, malaria is a public health concern, with severe malaria (SM) contributing a major
share of the disease burden in malaria endemic countries. In this context, identification and …

Genome-wide association study of susceptibility to respiratory syncytial virus hospitalization in young children< 5 years of age

AM Egeskov-Cavling, M Van Wijhe… - The Journal of …, 2024 - academic.oup.com
Background Worldwide, respiratory syncytial virus (RSV) infections are among the most
common causes of infant hospitalization. Host genetic factors influencing the risk and …

Innate immune activation and circulating inflammatory markers in preschool children

F Collier, C Chau, T Mansell, K Faye-Chauhan… - Frontiers in …, 2022 - frontiersin.org
Early childhood is characterised by repeated infectious exposures that result in inflammatory
responses by the innate immune system. In addition, this inflammatory response to infection …

Immunomodulatory markers and therapies for the management of infant respiratory syncytial virus infection

RA Loaiza, MA Farías, CA Andrade… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction The human respiratory syncytial virus (hRSV) is one of childhood diseases'
most common respiratory pathogens and is highly associated with lower respiratory tract …

Host inflammatory response is the major marker of severe respiratory syncytial virus infection in older adults

G Lui, CK Wong, M Chan, KC Chong, R Wong, I Chu… - Journal of Infection, 2021 - Elsevier
Objectives We aim to study the viral kinetics and host inflammatory response of RSV
infection in older adults, and their correlation with disease severity. Methods We performed a …

[HTML][HTML] What have we learned from animal studies of immune responses to respiratory syncytial virus infection?

SB Drysdale, RS Thwaites, J Price, D Thakur… - Journal of Clinical …, 2024 - Elsevier
Respiratory syncytial virus (RSV) is a common cause of severe respiratory tract infection at
the extremes of age and in vulnerable populations. However, it is difficult to predict the …

Molecular profiling of inflammatory mediators in human respiratory syncytial virus and human bocavirus infection

NA Alkubaisi, IM Aziz, AN Alsaleh, AF Alhetheel… - Genes, 2023 - mdpi.com
Infections due to human respiratory syncytial virus (HRSV) and human bocavirus (HBoV)
can mediate the release of several pro-inflammatory cytokines such as IL-6, IL-8, and TNF-α …

Nasopharyngeal and Peripheral Blood Type II Interferon Signature Evaluation in Infants during Respiratory Syncytial Virus Infection

F Savino, M Dini, A Clemente, C Calvi, A Pau… - Medicina, 2024 - mdpi.com
Background and Objectives: In this study, we applied one-step real time rt-PCR technology
type II INF signature to blood and nasopharyngeal (NPS) swabs of acute early recovery …