Molecular virology of SARS-CoV-2 and related coronaviruses

YA Kung, KM Lee, HJ Chiang, SY Huang… - Microbiology and …, 2022 - Am Soc Microbiol
SUMMARY Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The global COVID-19 pandemic continues to …

Betacoronavirus assembly: clues and perspectives for elucidating SARS-CoV-2 particle formation and egress

D Bracquemond, D Muriaux - MBio, 2021 - Am Soc Microbiol
In 2019, a new pandemic virus belonging to the betacoronavirus family emerged, severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This new coronavirus appeared in …

SARS-CoV-2 N protein antagonizes stress granule assembly and IFN production by interacting with G3BPs to facilitate viral replication

H Liu, Y Bai, X Zhang, T Gao, Y Liu, E Li… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 is the causative agent of the ongoing pandemic of coronavirus
disease 2019 (COVID-19) and poses a significant threat to global health. N protein (NP) …

Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication

X Tan, K Cai, J Li, Z Yuan, R Chen, H Xiao, C Xu, B Hu… - Cell Reports, 2023 - cell.com
ER-phagy is a form of autophagy that is mediated by ER-phagy receptors and selectively
degrades endoplasmic reticulum (ER). Coronaviruses have been shown to use the ER as a …

[HTML][HTML] Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

BA Chau, V Chen, AW Cochrane, LJ Parent… - Cell Reports, 2023 - cell.com
The leap of retroviruses and coronaviruses from animal hosts to humans has led to two
ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus …

Distinct motifs in the E protein are required for SARS-CoV-2 virus particle formation and lysosomal deacidification in host cells

K Miura, Y Suzuki, K Ishida, M Arakawa, H Wu… - Journal of …, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is a major public health
concern, but the mechanisms underlying its viral particle formation are not well understood …

ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis

J Zhu, GQ Liu, Z Sayyad, CM Goins… - Journal of …, 2024 - journals.asm.org
ABSTRACT Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like protein, is
covalently conjugated to host immune proteins such as MDA5 and IRF3 in a process called …

Molecular mechanisms of stress-induced reactivation in mumps virus condensates

X Zhang, S Sridharan, I Zagoriy, CE Oegema, C Ching… - Cell, 2023 - cell.com
Negative-stranded RNA viruses can establish long-term persistent infection in the form of
large intracellular inclusions in the human host and cause chronic diseases. Here, we …

Lessons learned and yet-to-Be learned on the importance of RNA structure in SARS-CoV-2 replication

M Bassett, M Salemi, B Rife Magalis - Microbiology and Molecular …, 2022 - Am Soc Microbiol
SUMMARY SARS-CoV-2, the etiological agent responsible for the COVID-19 pandemic, is a
member of the virus family Coronaviridae, known for relatively extensive (~ 30-kb) RNA …

[HTML][HTML] Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

L Delhaye, GD Moschonas, D Fijalkowska… - Cell Reports …, 2024 - cell.com
Protein-protein interactions play an important biological role in every aspect of cellular
homeostasis and functioning. Proximity labeling mass spectrometry-based proteomics …