At sites of vascular injury, platelets come into contact with subendothelial collagen, which
triggers their activation and the formation of a hemostatic plug. Besides glycoprotein Ib …

One early phase of atherosclerosis involves the recruitment of inflammatory cells from the
circulation and their transendothelial migration. This process is predominantly mediated by …

Background Variants of certain haemostatic genes (such as that encoding factor V Leiden)
are involved in the development of venous thrombosis, but studies of such variants in …

Collagens are important platelet activators in the vascular subendothelium and vessel wall.
Since the regulation of platelet activation is a key step in distinguishing normal haemostasis …

Integrins regulate cell-cell and cell-matrix adhesion and thereby play critical roles in tumor
progression and metastasis. Although work in preclinical models suggests that β1 integrins …

Background—Platelet aggregation plays an important role in arterial thrombosis in coronary
heart disease, stroke, and peripheral arterial disease. However, the contribution of genetic …

The adhesion and aggregation of platelets during hemostasis and thrombosis represents
one of the best-understood examples of cell–matrix adhesion. Platelets are exposed to a …

Three allelic differences in the α2 gene are associated with expression levels of the α2β1
integrin on the platelet surface. We have previously defined two linked silent polymorphisms …

Recently, we have shown that two alleles of the glycoprotein (GP) Ia gene, designated C807
and T807, are associated with low or high platelet GPIa-IIa density and consequently with …

Background The platelet membrane glycoprotein la/lla plays a major part in platelet function
as a primary receptor for collagen. A previous report showed a variation of glycoprotein la/lla …