Obesity as a clinical predictor for severe manifestation of dengue: a systematic review and meta-analysis

CY Chen, YY Chiu, YC Chen, CH Huang… - BMC Infectious …, 2023 - Springer
Background Severe dengue often leads to poor clinical outcomes and high mortality; as a
result, it is of vital importance to find prognostic factors associated with the severe form of …

Thymus, undernutrition, and infection: approaching cellular and molecular interactions

W Savino, J Durães, C Maldonado-Galdeano… - Frontiers in …, 2022 - frontiersin.org
Undernutrition remains a major issue in global health. Low protein-energy consumption,
results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that …

[HTML][HTML] The association of obesity and dengue severity in hospitalized adult patients

YY Chiu, CY Lin, LS Yu, WH Wang, CH Huang… - Journal of Microbiology …, 2023 - Elsevier
Background Obesity is associated with unfavorable outcomes for infectious diseases. Most
researches exploring the association between nutritional status and dengue severity have …

Transient blockade of type I interferon signalling promotes replication of dengue virus strain D2Y98P in adult wild-type mice

L Wilken, S Stelz, CK Prajeeth, GF Rimmelzwaan - Viruses, 2023 - mdpi.com
Dengue virus serotypes 1 to 4 (DENV1–4) place nearly half the global population at risk of
infection and the licenced tetravalent dengue vaccine fails to protect individuals who have …

[HTML][HTML] Associations of obesity and dengue-associated mortality, acute liver failure and mechanical ventilation in children with dengue shock syndrome

TT Nguyen, DT Nguyen, TTH Vo, OTH Dang… - Medicine, 2023 - journals.lww.com
Dengue-associated complications, including dengue shock syndrome, severe respiratory
distress, and pediatric acute liver failure (PALF), are associated with high mortality rates in …

Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice

R Honce, A Vazquez-Pagan, B Livingston… - Nature …, 2024 - nature.com
Metabolic disease is epidemiologically linked to severe complications upon influenza virus
infection, thus vaccination is a priority in this high-risk population. Yet, vaccine responses …

Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models

E Geerling, M Hameed, J Weger-Lucarelli… - Frontiers in …, 2022 - frontiersin.org
This review outlines the propensity for metabolic syndrome (MetS) to induce elevated
disease severity, higher mortality rates post-infection, and poor vaccination outcomes for …

Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines

C Chuong, C Cereghino, P Rai, TA Bates, M Oberer… - npj Vaccines, 2024 - nature.com
Alphaviruses are vector-borne, medically relevant, positive-stranded RNA viruses that cause
disease in animals and humans worldwide. Of this group, chikungunya virus (CHIKV) is the …

[HTML][HTML] Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS …

P Rai, C Chuong, T LeRoith, JW Smyth, J Panov… - Virology, 2021 - Elsevier
The COVID-19 pandemic has paralyzed the global economy and resulted in millions of
deaths globally. People with co-morbidities like obesity, diabetes and hypertension are at an …

In Situ Detection of Salmonid Alphavirus 3 (SAV3) in Tissues of Atlantic Salmon in a Cohabitation Challenge Model with a Special Focus on the Immune Response to …

H Tartor, LV Bernhardt, SN Mohammad, R Kuiper… - Viruses, 2023 - mdpi.com
Salmonid alphavirus strain 3 is responsible for outbreaks of pancreas disease in salmon
and rainbow trout in Norway. Although the extensive amount of research on SAV3 focused …