Hyaluronan is an extracellular and cell-surface-associated polysaccharide that is
traditionally regarded as a biological'goo'that participates in lubricating joints or holding …

Publisher Summary CD44 is a ubiquitous multistructural and multifunctional cell surface
adhesion molecule involved in cell–cell and cell–matrix interactions. CD44s is a single …

In this paper we present a hybrid mathematical model of the invasion of healthy tissue by a
solid tumour. In particular we consider early vascular growth, just after angiogenesis has …

Glioblastoma multiforme (GBM) is a malignant brain tumor characterized by diffuse
infiltration of single cells into the brain parenchyma, which is a process that relies in part on …

Cells can sense and respond to mechanical forces in fibrous extracellular matrices (ECMs)
over distances much greater than their size. This phenomenon, termed long-range force …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans
located primarily within the extracellular matrix (ECM). Versican, like other members of its …

Infiltration of the central nervous system by neoplastic cells in patients with glioblastoma
multiforme (GBM) leads to neurological dysfunction and eventually to death. The elucidation …

The survival benefit of anti–vascular endothelial growth factor (VEGF) therapy in metastatic
colorectal cancer (mCRC) patients is limited to a few months because of acquired …

The ongoing characterization of the genetic and epigenetic alterations in the gliomas has
already improved the classification of these heterogeneous tumors and enabled the …