Mannich bases in medicinal chemistry and drug design
G Roman - European journal of medicinal chemistry, 2015 - Elsevier
The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …
compounds that are generated from various substrates through the introduction of an …
Synthesis, Spectroscopic Analysis, and in Vitro/in Silico Biological Studies of Novel Piperidine Derivatives Heterocyclic Schiff‐Mannich Base Compounds
In the present study, 3‐substitued‐4‐(4‐hydroxybenzylidenamino)‐4, 5‐dihydro‐1H‐1, 2, 4‐
triazol‐5‐ones (S1‐8) were synthesized by treating 4‐hydroxybenzaldehyde (B) with eight …
triazol‐5‐ones (S1‐8) were synthesized by treating 4‐hydroxybenzaldehyde (B) with eight …
Piperazine-azole-fluoroquinolone hybrids: Conventional and microwave irradiated synthesis, biological activity screening and molecular docking studies
Abstract A series of new 1, 2, 4-triazole and 1, 3, 4-oxadiazole derivatives was obtained via
several steps sequential reactions of phenyl piperazine. Then, these compounds were …
several steps sequential reactions of phenyl piperazine. Then, these compounds were …
Synthesis and biological activities of some fluorine-and piperazine-containing 1, 2, 4-triazole thione derivatives
LY Zhang, BL Wang, YZ Zhan, Y Zhang, X Zhang… - Chinese Chemical …, 2016 - Elsevier
A series of fluorine-and piperazine-containing 1, 2, 4-triazole thione derivatives were
synthesized by the Mannich reaction of triazole intermediates with various substituted …
synthesized by the Mannich reaction of triazole intermediates with various substituted …
Synthesis, biological activity and structure activity relationship studies of novel conazole analogues via conventional, microwave and ultrasound mediated techniques
Triazole derivatives containing a piperazine nucleus (4a-d and 10) were prepared starting
from 1-(2-methoxyphenyl) piperazine or ethyl 4-(4-amino-2-fluorophenyl) piperazine-1 …
from 1-(2-methoxyphenyl) piperazine or ethyl 4-(4-amino-2-fluorophenyl) piperazine-1 …
Synthetic nicotinic/isonicotinic thiosemicarbazides: In vitro urease inhibitory activities and molecular docking studies
Nicotinic and isonicotinic thiosemicarbazide or hydrazine carbothioamides 3–27 were
synthesized and the structures of synthetic compounds were elucidated by various …
synthesized and the structures of synthetic compounds were elucidated by various …
Novel azole-functionalited flouroquinolone hybrids: Design, conventional and microwave irradiated synthesis, evaluation as antibacterial and antioxidant agents
M Mentese, N Demirbas, A Mermer… - Letters in Drug …, 2018 - ingentaconnect.com
Background: The synthesis of new hybrid molecules consisting of several heterocyclic
pharmacophores namely fluoroquinolone, 1, 2, 4-triazole, 1, 3, 4-oxadiazole and piperazine …
pharmacophores namely fluoroquinolone, 1, 2, 4-triazole, 1, 3, 4-oxadiazole and piperazine …
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl) thiazole-5-yl]-4-substituted-3-
substituted benzylthio-4H-1, 2, 4-triazole derivatives were synthesized, and evaluated for …
substituted benzylthio-4H-1, 2, 4-triazole derivatives were synthesized, and evaluated for …
Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
S Basoglu Ozdemir, Y Uygun Cebeci… - Heterocyclic …, 2017 - degruyter.com
The hydrazide 5, that was obtained from 1-(4-fluorophenyl) piperazine (1), was converted to
the corresponding carbothioamides 6a–c by the reaction with alkyl (aryl) isothiocyanates …
the corresponding carbothioamides 6a–c by the reaction with alkyl (aryl) isothiocyanates …
Synthesis and biological evaluation of new Mannich and Schiff bases containing 1, 2, 4-triazole and 1, 3, 4-oxadiazole nucleus
S Ceylan - Medicinal Chemistry Research, 2016 - Springer
(Pyridine-3-yl)-1, 3, 4-oxadiazole-2-thiole 2, obtaining starting from nicotinic acid hydrazide
were converted to the corresponding Mannich bases (3a–c) by the reaction with several …
were converted to the corresponding Mannich bases (3a–c) by the reaction with several …