Non-publication of large randomized clinical trials: cross sectional analysis

CW Jones, L Handler, KE Crowell, LG Keil, MA Weaver… - Bmj, 2013 - bmj.com
Objective To estimate the frequency with which results of large randomized clinical trials
registered with ClinicalTrials. gov are not available to the public. Design Cross sectional …

Registration of published randomized trials: a systematic review and meta-analysis

L Trinquart, AG Dunn, FT Bourgeois - BMC medicine, 2018 - Springer
Background Prospective trial registration is a powerful tool to prevent reporting bias. We
aimed to determine the extent to which published randomized controlled trials (RCTs) were …

Trends in global clinical trial registration: an analysis of numbers of registered clinical trials in different parts of the world from 2004 to 2013

RF Viergever, K Li - BMJ open, 2015 - bmjopen.bmj.com
Objectives To analyse developments (and their causes) in the number and proportion of
clinical trials that were registered in different parts of the world after the International …

Clinical trial registration, reporting, publication and FDAAA compliance: a cross-sectional analysis and ranking of new drugs approved by the FDA in 2012

JE Miller, D Korn, JS Ross - BMJ open, 2015 - bmjopen.bmj.com
Objective To evaluate clinical trial registration, reporting and publication rates for new drugs
by:(1) legal requirements and (2) the ethical standard that all human subjects research …

Is mandatory prospective trial registration working to prevent publication of unregistered trials and selective outcome reporting? An observational study of five …

A Scott, JJ Rucklidge, RT Mulder - PloS one, 2015 - journals.plos.org
Objective To address the bias occurring in the medical literature associated with selective
outcome reporting, in 2005, the International Committee of Medical Journal Editors (ICMJE) …

Antioxidants for pain in chronic pancreatitis

UA Ali, S Jens, ORC Busch, F Keus… - Cochrane Database …, 2014 - cochranelibrary.com
Background Reduced intake and absorption of antioxidants due to pain and malabsorption
are probable causes of the lower levels of antioxidants observed in patients with chronic …

Prospective registration and reporting of trial number in randomised clinical trials: global cross sectional study of the adoption of ICMJE and Declaration of Helsinki …

M Al-Durra, RP Nolan, E Seto, JA Cafazzo - bmj, 2020 - bmj.com
Objectives To evaluate the compliance with prospective registration and inclusion of the trial
registration number (TRN) in published randomised controlled trials (RCTs), and to analyse …

Clinical trial registration was not an indicator for low risk of bias

CM Farquhar, MG Showell, EAE Showell… - Journal of clinical …, 2017 - Elsevier
Objectives To determine the prevalence of registered trials and to evaluate the risk of bias
between registered and unregistered clinical trials. Study Design and Setting The Cochrane …

Trial registration numbers are underreported in biomedical publications

FT van de Wetering, RJPM Scholten, T Haring… - PLoS …, 2012 - journals.plos.org
Context Since September 2005, the International Committee of Medical Journal Editors
(ICMJE) has required that randomised controlled trials (RCTs) are prospectively registered …

A systematic review of the processes used to link clinical trial registrations to their published results

R Bashir, FT Bourgeois, AG Dunn - Systematic reviews, 2017 - Springer
Background Studies measuring the completeness and consistency of trial registration and
reporting rely on linking registries with bibliographic databases. In this systematic review, we …