Overview of histone modification
Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …
parents to offspring. From years of studies, people have found that histone modifications …
A short guide to histone deacetylases including recent progress on class II enzymes
SY Park, JS Kim - Experimental & molecular medicine, 2020 - nature.com
The interaction between histones and DNA is important for eukaryotic gene expression. A
loose interaction caused, for example, by the neutralization of a positive charge on the …
loose interaction caused, for example, by the neutralization of a positive charge on the …
Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
Y Hai, DW Christianson - Nature chemical biology, 2016 - nature.com
Abstract Histone deacetylase 6 (HDAC6) is a critical target for drug design because of its
role in oncogenic transformation and cancer metastasis, and is unique among all histone …
role in oncogenic transformation and cancer metastasis, and is unique among all histone …
Targeting metalloenzymes for therapeutic intervention
AY Chen, RN Adamek, BL Dick, CV Credille… - Chemical …, 2018 - ACS Publications
Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …
Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy
A Alqahtani, K Choucair, M Ashraf… - Future science …, 2019 - Taylor & Francis
Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process
results in aberrant gene expression in various diseases, including cancer. The …
results in aberrant gene expression in various diseases, including cancer. The …
Histone modifications and their role in epigenetics of atopy and allergic diseases
B Alaskhar Alhamwe, R Khalaila, J Wolf… - Allergy, Asthma & …, 2018 - Springer
This review covers basic aspects of histone modification and the role of posttranslational
histone modifications in the development of allergic diseases, including the immune …
histone modifications in the development of allergic diseases, including the immune …
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility
C Tatone, G Di Emidio, A Barbonetti… - Human …, 2018 - academic.oup.com
Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …
that catalyze post-translational modifications of proteins. Together, they respond to …
Structural insights into HDAC6 tubulin deacetylation and its selective inhibition
We report crystal structures of zebrafish histone deacetylase 6 (HDAC6) catalytic domains in
tandem or as single domains in complex with the (R) and (S) enantiomers of trichostatin A …
tandem or as single domains in complex with the (R) and (S) enantiomers of trichostatin A …
Post-translational protein acetylation: an elegant mechanism for bacteria to dynamically regulate metabolic functions
Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …
to an existing proteome. The large number of known PTMs highlights the many ways that …
Oxidative stress signaling to chromatin in health and disease
S Kreuz, W Fischle - Epigenomics, 2016 - Taylor & Francis
Oxidative stress has a significant impact on the development and progression of common
human pathologies, including cancer, diabetes, hypertension and neurodegenerative …
human pathologies, including cancer, diabetes, hypertension and neurodegenerative …