International union of basic and clinical pharmacology. CI. Structures and small molecule modulators of mammalian adenylyl cyclases
Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms
KF Ostrom, JE LaVigne, TF Brust… - Physiological …, 2022 - journals.physiology.org
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …
Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of …
R Shinohara, M Taniguchi, AT Ehrlich… - Molecular …, 2018 - nature.com
Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the
dysfunction of prefrontal dopamine has been associated with cognitive and emotional …
dysfunction of prefrontal dopamine has been associated with cognitive and emotional …
Noradrenaline activation of hippocampal dopamine D1 receptors promotes antidepressant effects
K Kobayashi, K Shikano, M Kuroiwa… - Proceedings of the …, 2022 - National Acad Sciences
Dopamine D1 receptors (D1Rs) in the hippocampal dentate gyrus (DG) are essential for
antidepressant effects. However, the midbrain dopaminergic neurons, the major source of …
antidepressant effects. However, the midbrain dopaminergic neurons, the major source of …
Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects
E Montalban, A Giralt, L Taing, EHS Schut… - Molecular …, 2022 - nature.com
Forebrain dopamine-sensitive (dopaminoceptive) neurons play a key role in movement,
action selection, motivation, and working memory. Their activity is altered in Parkinson's …
action selection, motivation, and working memory. Their activity is altered in Parkinson's …
C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action
A Murza, E Besserer-Offroy, J Cote… - Journal of medicinal …, 2015 - ACS Publications
Apelin is the endogenous ligand of the APJ receptor, a member of the G protein-coupled
receptor family. This system plays an important role in the regulation of blood pressure and …
receptor family. This system plays an important role in the regulation of blood pressure and …
Elucidation of the Molecular Mechanism Underlying Lippia citriodora(Lim.)-Induced Relaxation and Anti-Depression
M Sabti, K Sasaki, C Gadhi, H Isoda - International journal of molecular …, 2019 - mdpi.com
Lippia citriodora ethanolic extract (VEE) and verbascoside (Vs), a phenypropanoid
glycoside, have been demonstrated to exert relaxant and anxiolytic properties. However, the …
glycoside, have been demonstrated to exert relaxant and anxiolytic properties. However, the …
(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein-and β-arrestin-mediated signaling
JA Meade, RB Free, NR Miller, LS Chun, TB Doyle… - …, 2015 - Springer
Abstract Rationale (−)-Stepholidine is a tetrahydroberberine alkaloid that is known to interact
with dopamine receptors and has also been proposed as a novel antipsychotic agent. Its …
with dopamine receptors and has also been proposed as a novel antipsychotic agent. Its …
Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells
P Yu, M Sun, MV Van Anthony, Y Zhang, EJ Weinman… - Cellular signalling, 2014 - Elsevier
Dopamine D 1-like receptors (D 1 R and D 5 R) stimulate adenylyl cyclase (AC) activity,
whereas the D 2-like receptors (D 2, D 3 and D 4) inhibit AC activity. D 1 R, but not the D 5 R …
whereas the D 2-like receptors (D 2, D 3 and D 4) inhibit AC activity. D 1 R, but not the D 5 R …
Renal proximal tubule Na, K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1
M Taub, S Garimella, D Kim, T Rajkhowa, F Cutuli - Cellular signalling, 2015 - Elsevier
Sodium reabsorption by the kidney is regulated by locally produced natriuretic and anti-
natriuretic factors, including dopamine and norepinephrine, respectively. Previous studies …
natriuretic factors, including dopamine and norepinephrine, respectively. Previous studies …