Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

MicroRNAs (miRNAs) are small RNAs that do not encode for proteins and play key roles in
the regulation of gene expression. miRNAs are involved in a comprehensive range of …

Oxygen maintains the homeostasis of an organism in a delicate balance in different tissues
and organs. Under hypoxic conditions, hypoxia-inducible factors (HIFs) are specific and …

Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals,
evasion of apoptosis, cellular stress, and sustained angiogenesis, invasiveness and …

Oxidative stress, caused by the over production of oxidants or inactivity of antioxidants, can
modulate the redox state of several target proteins such as tyrosine kinases, mitogen …

Background Manganese overexposure can induce neurotoxicity, lead to manganism and
result in clinical manifestations similar to those of parkinsonism. However, the underlying …

Objective To investigate the regulation of adiponectin/miR-711 on TLR4/NF-κB-mediated
inflammatory response and diabetic cardiomyocyte apoptosis. Methods Diabetes models …

Apoptosis is a complex and highly self-regulating form of cell death, which is an important
cause of the continuous decline in ventricular function and is widely involved in the …

BACKGROUND Cooking oil is an indispensable component of the human diet. However,
oils usually undergo thermal oxidation. Oxidized soybean oil (OSO) has been shown to have …

Pyogenic spondylodiscitis can cause severe osteolytic and destructive lesions in the spine.
Elderly or immunocompromised individuals are particularly susceptible to infectious …