Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Osteoporosis is a common metabolic bone disease that results from the imbalance of
homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic …

Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular
components are selectively digested for the recycling of nutrients and energy. This process …

Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells
responsible for bone formation, osteoclasts (OC), the cells specialized for bone resorption …

Vital osteocytes have been well known to function as an important orchestrator in the
preservation of robustness and fidelity of the bone remodeling process. Nevertheless, some …

Macroautophagy/autophagy is a highly regulated process involved in the turnover of
cytosolic components, however its pivotal role in maintenance of bone homeostasis remains …

Autophagy is a conserved lysosomal degradation process that has important roles in both
normal human physiology and disease. However, the function of autophagy in bone …

From an evolutionary perspective, the major function of bone is to provide stable sites for
muscle attachment and affording protection of vital organs, especially the heart and lungs …

Autophagy is an evolutionary conserved and highly regulated recycling process of cellular
wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic …

Autophagy is an evolutionarily conserved intracellular process and is considered one of the
main catabolism pathways. In the process of autophagy, cells are digested nonselectively or …