[HTML][HTML] Antimicrobial peptides for combating drug-resistant bacterial infections

J Xuan, W Feng, J Wang, R Wang, B Zhang, L Bo… - Drug Resistance …, 2023 - Elsevier
The problem of drug resistance due to long-term use of antibiotics has been a concern for
years. As this problem grows worse, infections caused by multiple bacteria are expanding …

Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds

A Pfalzgraff, K Brandenburg, G Weindl - Frontiers in pharmacology, 2018 - frontiersin.org
Alarming data about increasing resistance to conventional antibiotics are reported, while at
the same time the development of new antibiotics is stagnating. Skin and soft tissue …

Synergy by perturbing the gram-negative outer membrane: opening the door for gram-positive specific antibiotics

CMJ Wesseling, NI Martin - ACS Infectious Diseases, 2022 - ACS Publications
New approaches to target antibacterial agents toward Gram-negative bacteria are key, given
the rise of antibiotic resistance. Since the discovery of polymyxin B nonapeptide as a potent …

Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus

MF Mohamed, A Abdelkhalek, MN Seleem - Scientific reports, 2016 - nature.com
Methicillin-resistant Staphylococcus aureus (MRSA) infections present a serious challenge
because of the emergence of resistance to numerous conventional antibiotics. Due to their …

Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a (1-21) NH2 as a reliable strategy for antipseudomonal drugs

B Casciaro, M Moros, S Rivera-Fernandez, A Bellelli… - Acta biomaterialia, 2017 - Elsevier
Naturally occurring antimicrobial peptides (AMPs) hold promise as future therapeutics
against multidrug resistant microorganisms. Recently, we have discovered that a derivative …

[HTML][HTML] Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components

F Savini, MR Loffredo, C Troiano, S Bobone… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Antimicrobial peptides (AMPs) selectively kill bacteria by disrupting their cell membranes,
and are promising compounds to fight drug-resistant microbes. Biophysical studies on …

Esculentin (1-21), an amphibian skin membrane-active peptide with potent activity on both planktonic and biofilm cells of the bacterial pathogen Pseudomonas …

V Luca, A Stringaro, M Colone, A Pini… - Cellular and molecular …, 2013 - Springer
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that forms sessile
communities, named biofilms. The non-motile forms are very difficult to eradicate and are …

Antimicrobial peptides: amphibian host defense peptides

J Patocka, E Nepovimova, B Klimova… - Current medicinal …, 2019 - ingentaconnect.com
Antimicrobial Peptides (AMPs) are one of the most common components of the innate
immune system that protect multicellular organisms against microbial invasion. The vast …

Short native antimicrobial peptides and engineered ultrashort lipopeptides: similarities and differences in cell specificities and modes of action

ML Mangoni, Y Shai - Cellular and Molecular Life Sciences, 2011 - Springer
Due to the rapid emergence of resistant microbes to the currently available antibiotics,
cationic antimicrobial peptides have attracted considerable interest as a possible new …

d-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions

A Di Grazia, F Cappiello, H Cohen, B Casciaro, V Luca… - Amino acids, 2015 - Springer
Naturally occurring antimicrobial peptides (AMPs) represent promising future antibiotics. We
have previously isolated esculentin-1a (1-21) NH 2, a short peptide derived from the frog …