The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …

Photodissociation mass spectrometry combines the ability to activate and fragment ions
using photons with the sensitive detection of the resulting product ions by mass …

The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …

METHODS Herein we describe alternative dissociation methods commonly employed within
mass spectrometry with an emphasis on the outcomes of probing native protein complexes …

The channel kinases TRPM6 and TRPM7 are fusion proteins with an ion transport domain
and an enzymatically active kinase domain. TRPM7 has been found in every mammalian …

The ability to localize phosphosites to specific amino acid residues is crucial to translating
phosphoproteomic data into biological meaningful contexts. In a companion manuscript …

Using concurrent IR photoactivation during electron transfer dissociation (ETD) reactions, ie,
activated ion ETD (AI-ETD), significantly increases dissociation efficiency resulting in …

We report a hybrid fragmentation method involving electron transfer dissociation (ETD)
combined with ultraviolet photodissociation (UVPD) at 193 nm for analysis of intact proteins …

Advances in liquid chromatography tandem mass spectrometry (LC–MS/MS) have permitted
phosphoproteomic analysis on a grand scale, but ongoing challenges specifically …

Herein we report the successful implementation of the consecutive and simultaneous
photodissociation with high (213 nm) and low (10.6 μm) energy photons (HiLoPD, high-low …