POMC neuronal heterogeneity in energy balance and beyond: an integrated view

C Quarta, M Claret, LM Zeltser, KW Williams… - Nature …, 2021 - nature.com
Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

Neuropeptide Y is an immunomodulatory factor: direct and indirect

W Chen, Y Liu, W Liu, Y Zhou, H He, S Lin - Frontiers in immunology, 2020 - frontiersin.org
Neuropeptide Y (NPY), which is widely distributed in the nervous system, is involved in
regulating a variety of biological processes, including food intake, energy metabolism, and …

Adipose tissue, systematic inflammation, and neurodegenerative diseases

APA Boleti, PHO Cardoso, BEF Frihling… - Neural Regeneration …, 2023 - journals.lww.com
Obesity is associated with several diseases, including mental health. Adipose tissue is
distributed around the internal organs, acting in the regulation of metabolism by storing and …

Functional heterogeneity of POMC neurons relies on mTORC1 signaling

N Saucisse, W Mazier, V Simon, E Binder, C Catania… - Cell Reports, 2021 - cell.com
Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However,
these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric …

Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based on gut microbiota and lipid …

Y Dong, H Song, A J. Holmes, J Yan… - … Journal of Food …, 2023 - Taylor & Francis
Growing evidence supports the efficacy of ketogenic diets for inducing weight loss, but there
are also potential health risks due to their unbalanced nutrient composition. We aim at …

Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer's disease

L Carrero, D Antequera, I Alcalde, D Megías… - Acta Neuropathologica …, 2023 - Springer
The circadian clock is synchronized to the 24 h day by environmental light which is
transmitted from the retina to the suprachiasmatic nucleus (SCN) primarily via the …

Neurotransmitters in type 2 diabetes and the control of systemic and central energy balance

A Al-Sayyar, MM Hammad, MR Williams, M Al-Onaizi… - Metabolites, 2023 - mdpi.com
Efficient signal transduction is important in maintaining the function of the nervous system
across tissues. An intact neurotransmission process can regulate energy balance through …

[HTML][HTML] Jinkui Shenqi pills ameliorate diabetes by regulating hypothalamic insulin resistance and POMC/AgRP expression and activity

S Zhang, Y Zhang, Z Wen, Y Yang, T Bu, R Wei… - Phytomedicine, 2024 - Elsevier
Background Research on the imbalance of proopiomelanocortin (POMC)/agouti-related
protein (AgRP) neurons in the hypothalamus holds potential insights into the …

Activation of the ARCPOMC→MeA Projection Reduces Food Intake

E Kwon, YH Jo - Frontiers in neural circuits, 2020 - frontiersin.org
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC)
plays an essential role in the control of food intake and energy expenditure. Melanocortin-4 …

Activation of POMC neurons to adiponectin participating in EA-mediated improvement of high-fat diet IR mice

W Xu, J Li, C Ji, D Fang, L Yao, N Xu… - Frontiers in Neuroscience, 2023 - frontiersin.org
Background Insulin resistance (IR) is one of the common pathological manifestations of
metabolic-related diseases, and the prevalence of relevant diseases is high. Acupuncture is …