Quercetin is a flavonoid abundantly found in fruits and vegetables. It possesses a wide
spectrum of biological activities, thus suggesting a role in disease prevention and health …

Osteoporosis (OP) is characterized by reduced bone mass, decreased strength, and
enhanced bone fragility fracture risk. Activating transcription factor 4 (ATF4) plays a role in …

The bone defects caused by trauma are inevitably accompanied by soft tissue damage. The
development of multifunctional bioactive biomaterials with integrated bone and soft tissue …

The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly
regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and …

Emerging evidence supports that osteogenic differentiation of skeletal progenitors is a key
determinant of overall bone formation and bone mass. Despite extensive studies showing …

Atherosclerosis (AS), one of the most common types of cardiovascular disease, has initially
been attributed to the accumulation of fats and fibrous materials. However, more and more …

Osteogenesis imperfecta (OI) is a heterogeneous heritable skeletal dysplasia characterized
by bone fragility and deformity, growth deficiency, and other secondary connective tissue …

Bone is a highly vascularized tissue that relies on a close spatial and temporal interaction
between blood vessels and bone cells. As a result, angiogenesis is critical for bone …

Background An imbalance of osteoblasts (OBs) and osteoclasts (OCs) in a chronic
inflammatory microenvironment is an important pathological factor leading to osteoporosis …

Activation of Wnt signaling leads to high bone density. The R-spondin family of four secreted
glycoproteins (Rspo1-4) amplifies Wnt signaling. In humans, RSPO3 variants are strongly …