ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …

The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …

Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of
proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that …

Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …

The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …

Host organisms utilise a range of genetically encoded cell death programmes in response to
pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their …

Cytosolic mitochondrial DNA (mtDNA) activates cGAS-mediated antiviral immune
responses, but the mechanism by which RNA viruses stimulate mtDNA release remains …

Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

Viruses are ubiquitous intracellular genetic parasites that heavily rely on the infected cell to
complete their replication life cycle. This dependency on the host machinery forces viruses …