Applying a high voltage to a liquid passing through a capillary disintegrates the liquid
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …

Abstract “Natively unfolded” proteins occupy a unique niche within the protein kingdom in
that they lack ordered structure under conditions of neutral pH in vitro. Analysis of amino …

Many globular proteins are good emulsifiers or stabilizers for oil-in-water emulsions. It is
generally recognized in the field that globular proteins tend to undergo a structural unfolding …

In the search for the molecular mechanism of insulin fibrillation, the kinetics of insulin fibril
formation were studied under different conditions using the fluorescent dye thioflavin T …

The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

Natively unfolded or intrinsically unstructured proteins constitute a unique group of the
protein kingdom. The evolutionary persistence of such proteins represents strong evidence …

Publisher Summary This chapter describes the present state of the studies of the molten
globule state and its role in protein folding and physiological processes. Recent data on the …

Transthyretin (TTR) amyloid fibril formation is observed during partial acid denaturation and
while refolding acid-denatured TTR, implying that amyloid fibril formation results from the …