Myeloperoxidase (MPO)-specific antineutrophil cytoplasmic antibody (ANCA)-associated
vasculitis (MPO-ANCA-associated vasculitis) is one of two major ANCA-associated vasculitis …

Viral vectors play a pivotal role in the field of gene therapy, with several related drugs having
already gained clinical approval from the EMA and FDA. However, numerous viral gene …

Hypertension is a primary modifiable risk factor for cardiovascular diseases, which often
induces renal end-organ damage and complicates chronic kidney disease (CKD). In the …

Gain-of-function mutations in STING cause STING-associated vasculopathy with onset in
infancy (SAVI) characterized by early-onset systemic inflammation, skin vasculopathy, and …

Abstract Background Advanced prostate cancer (PCa) will develop into castration-resistant
prostate cancer (CRPC) and lead to poor prognosis. As the primary subtype of CRPC …

Cyclic GMP-AMP synthetase (cGAS), recognized as the primary DNA sensor within cells,
possesses the capability to identify foreign DNA molecules along with free DNA fragments …

Acute and chronic inflammation are important pathologies of benign airway stenosis (BAS)
fibrosis, which is a frequent complication of critically ill patients. cGAS-STING signalling has …

Background Acute lung injury (ALI)-induced acute respiratory syndromes is a critical
pathological sequala of sepsis. Araloside A (ARA), extracted from Aralia taibaiensis …

Objectives ANCA-associated vasculitis (AAV) includes granulomatosis with polyangiitis
(GPA) and microscopic polyangiitis (MPA). ANCA triggers neutrophil extracellular trap …

Introduction Giant cell arteritis (GCA) is a vasculitis of the medium-and large-sized arteries.
Interferon type I (IFN-I) is increasingly recognized as a key player in autoimmune diseases …