The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …

Immune signalling pathways convert pathogenic stimuli into cytosolic events that lead to the
resolution of infection. Upon ligand engagement, immune receptors together with their …

Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children
in North America and one of the leading causes of death of infants less than 1 year of age …

The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …

Viruses rely on the reprogramming of cellular processes to enable efficient viral replication;
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …

Human respiratory syncytial virus (RSV) is an enveloped, nonsegmented negative-strand
RNA virus of family Paramyxoviridae. RSV is the most complex member of the family in …

Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

Infection of cells by respiratory syncytial virus induces the formation of cytoplasmic inclusion
bodies (IBs) where all the components of the viral RNA polymerase complex are …

Respiratory syncytial virus (RSV) is one of the most important viral pathogens causing
respiratory tract infection in infants, the elderly and people with poor immune function, which …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …