Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

BACKGROUND One or more brief episodes of coronary artery occlusion protect or"
precondition" the myocardium perfused by that artery from a subsequent episode of …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

In experimental studies in the dog, total proximal coronary artery occlusions of up to 15
minutes result in reversible injury, meaning that the myocytes survive this insult. The 15 …

On July 2–3, 1996, the National Heart, Lung, and Blood Institute sponsored a workshop in
Columbia, Md, entitled “The Medical and Cellular Implications of Myocardial Stunning …

Remote ischemic preconditioning (rIPC), induced by cycles of transient limb ischemia and
reperfusion (IR), is cardioprotective. The optimal rIPC-algorithm is not established. We …

Background In the experimental setting, it has been demonstrated that preconditioning
myocardium before prolonged occlusion with brief ischemic episodes affords substantial …

Cardiac surgery and some noncardiac procedures are associated with a significant risk of
perioperative cardiac morbid events. Experimental data indicate that clinical concentrations …

BACKGROUND Brief episodes of ischemia render the heart more resistant to subsequent
ischemia; this phenomenon has been called ischemic preconditioning. In some animal …