Applications of cucurbiturils in medicinal chemistry and chemical biology

D Das, KI Assaf, WM Nau - Frontiers in chemistry, 2019 - frontiersin.org
The supramolecular chemistry of cucurbit [n] urils (CB n) has been rapidly developing to
encompass diverse medicinal applications, including drug formulation and delivery …

Cucurbituril‐based biomacromolecular assemblies

YH Liu, YM Zhang, HJ Yu, Y Liu - Angewandte Chemie, 2021 - Wiley Online Library
The construction of controlled biomacromolecular assemblies has become a thriving area of
supramolecular chemistry. In this context, cucurbiturils (CBs), a class of macrocyclic …

Molecular engineering of noncovalent dimerization

G Wu, F Li, B Tang, X Zhang - Journal of the American Chemical …, 2022 - ACS Publications
Dimers are probably the simplest model to facilitate the understanding of fundamental
physical and chemical processes that take place in much-expanded systems like …

Chiral adaptive recognition with sequence specificity of aromatic dipeptides in aqueous solution by an achiral cage

L Cheng, P Tian, H Duan, Q Li, X Song, A Li… - Chemical Science, 2023 - pubs.rsc.org
Sequence-specific recognition of peptides and proteins by synthetic compounds or systems
remains a huge challenge in biocompatible media. Here, we report the chiral adaptive …

Recent advances in design of fluorescence-based assays for high-throughput screening

X Fang, Y Zheng, Y Duan, Y Liu, W Zhong - Analytical chemistry, 2018 - ACS Publications
Significant improvements in disease management have been achieved in the past few
decades. Using cancer as an example, survival rates have increased dramatically in …

Cucurbit [7] uril macrocyclic sensors for optical fingerprinting: predicting protein structural changes to identifying disease-specific amyloid assemblies

N Das Saha, S Pradhan, R Sasmal… - Journal of the …, 2022 - ACS Publications
In a three-dimensional (3D) representation, each protein molecule displays a specific
pattern of chemical and topological features, which are altered during its misfolding and …

Host-guest liquid gating mechanism with specific recognition interface behavior for universal quantitative chemical detection

H Wang, Y Fan, Y Hou, B Chen, J Lei, S Yu… - Nature …, 2022 - nature.com
Universal visual quantitative chemical detection technology has emerged as an increasingly
crucial tool for convenient testing with immediate results in the fields of environmental …

Cucurbiturils brighten Au nanoclusters in water

T Jiang, G Qu, J Wang, X Ma, H Tian - Chemical science, 2020 - pubs.rsc.org
Gold nanoclusters (AuNCs) with well-defined atomically precise structures present
promising emissive prospects for excellent biocompatibility and optical properties. However …

Molecular recognition of peptides and proteins by cucurbit [n] urils: systems and applications

L Armstrong, SL Chang, N Clements, Z Hirani… - Chemical Society …, 2024 - pubs.rsc.org
The development of methodology for attaching ligand binding sites to proteins of interest has
accelerated biomedical science. Such protein tags have widespread applications as well as …

A Closed Cavity Strategy for Selective Dipeptide Binding by a Polyaromatic Receptor in Water

M Shuto, R Sumida, M Yuasa, T Sawada… - JACS Au, 2023 - ACS Publications
Precise recognition of peptides is a daunting task owing to the substantial number of
available amino acids and their combination into various oligo/polymeric structures in …