Frontiers in Acute Pain Management: Emerging Concepts in Pain Pathways and the Role of VX-548 as a Novel NaV1. 8 Inhibitor: A Narrative Review
AD Kaye, ES Everett, AM Lehuquet, JW Mason… - Current Pain and …, 2024 - Springer
Abstract Purpose of Review Despite ongoing research into alternative postsurgical pain
treatments, opioids remain widely used analgesics regardless of associated adverse effects …
treatments, opioids remain widely used analgesics regardless of associated adverse effects …
State-Dependent Inhibition of Nav1. 8 Sodium Channels by VX-150 and VX-548
ABSTRACT Nav1. 8 sodium channels (Nav1. 8) are an attractive therapeutic target for pain
because they are prominent in primary pain-sensing neurons with little expression in most …
because they are prominent in primary pain-sensing neurons with little expression in most …
[HTML][HTML] Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain
B Zhang, X Shi, X Liu, Y Liu, X Li, Q Wang… - Journal of …, 2024 - Elsevier
This research study focuses on addressing the limitations of current neuropathic pain (NP)
treatments by developing a novel dual-target modulator, E0199, targeting both Na V 1.7, Na …
treatments by developing a novel dual-target modulator, E0199, targeting both Na V 1.7, Na …
Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons
CJ LeBlang, MF Pazyra-Murphy, ES Silagi, S Dasgupta… - bioRxiv, 2024 - biorxiv.org
Sensory neurons generated from induced pluripotent stem cells (iSNs) are used to model
human peripheral neuropathies, however current differentiation protocols produce sensory …
human peripheral neuropathies, however current differentiation protocols produce sensory …
Conservation of Ligand Binding Between Voltage-Gated Sodium and T-Type Calcium Channels
RK Finol-Urdaneta, JR McArthur, DJ Adams - Ion Channels as Targets in …, 2024 - Springer
In vertebrates, two types of ion channels are responsible for amplifying electrical signals and
facilitating neurotransmission: voltage-gated sodium (Nav1) and calcium (Cav3) channels …
facilitating neurotransmission: voltage-gated sodium (Nav1) and calcium (Cav3) channels …
Discovery of a novel compound E0199 that simultaneously targets both peripheral NaV and KV7 ion channels to alleviate neuropathic pain
B Zhang, X Shi, X Liu, Y Liu, Q Wang, X Li… - Authorea …, 2024 - essopenarchive.org
This research focuses on addressing the limitations of current neuropathic pain (NP)
treatments by developing a novel dual-target modulator, E0199, targeting both NaV1. 7, 1.8 …
treatments by developing a novel dual-target modulator, E0199, targeting both NaV1. 7, 1.8 …
[引用][C] Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1. 8 with a Unique Mechanism of …
JM Gilchrist, ND Yang, V Jiang, BD Moyer - Molecular Pharmacology, 2024 - ASPET