ABC transporters catalyze transport reactions, such as the high-affinity uptake of
micronutrients into bacteria and the export of cytotoxic compounds from mammalian cells …

Conditional gene expression has greatly facilitated the examination of the functions of
particular gene products. Using the Cre/lox P switching expression system, we plan to …

Distance distributions between paramagnetic centers in the range of 1.8 to 6 nm in
membrane proteins and up to 10 nm in deuterated soluble proteins can be measured by the …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

Comprehensive knowledge of the human leukocyte antigen (HLA) class-I and class-II
peptides presented to T-cells is crucial for designing innovative therapeutics against cancer …

Recent advances in cancer immunotherapy have clearly shown that checkpoint-based
immunotherapy is effective in a small subgroup of cancer patients. However, no effective …

Recognition and elimination of virally or malignantly transformed cells are pivotal tasks of
the adaptive immune system. For efficient immune detection, snapshots of the cellular …

Cellular immunity against viral infection and tumour cells depends on antigen presentation
by major histocompatibility complex class I (MHC I) molecules. Intracellular antigenic …

ATP binding cassette (ABC) transporters mediate vital transport processes in every living
cell. ATP hydrolysis, which fuels transport, displays positive cooperativity in numerous ABC …

Electron paramagnetic resonance (EPR) spectroscopy is a very powerful biophysical tool
that can provide valuable structural and dynamic information about a wide variety of …