Cells are subjected to endogenous [eg, reactive oxygen species (ROS), replication stress]
and exogenous insults (eg, UV light, ionizing radiation, and certain chemicals), which can …

Myofibre necrosis is a central pathogenic process in muscular dystrophies (MD). As post-
lesional regeneration cannot fully compensate for chronic myofibre loss, interstitial tissue …

Diabetic peripheral neuropathy (DPN) is a pervasive and incapacitating sequela of diabetes,
affecting a significant proportion of those diagnosed with the disease, yet an effective …

Muscular dystrophies are a heterogeneous group of genetic muscle-wasting disorders that
are subdivided based on the region of the body impacted by muscle weakness as well as …

Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to
the pathogenesis of muscular dystrophy (MD). Here, we showed that defects in the …

The research on laminin α2 chain-deficient congenital muscular dystrophy (LAMA2-CMD)
advanced rapidly in the last few decades, largely due to availability of good mouse models …

Background: Merosin-deficient congenital muscular dystrophy type 1A (MDC1A), also
known as laminin-α2 chain-deficient congenital muscular dystrophy (LAMA2-MD), is an …

LAMA2, coding for the laminin-α2 chain, is a crucial ECM component, particularly abundant
in skeletal muscle. Mutations in LAMA2 trigger the often-lethal LAMA2-congenital muscular …

Muscular dystrophies (MDs) are a heterogeneous group of diseases of genetic origin
characterized by progressive skeletal muscle degeneration and weakness. There are …

LAMA2-congenital muscular dystrophy (LAMA2-CMD) is the most common congenital
muscular dystrophy. This often-lethal disease is triggered by mutations in LAMA2, coding for …