Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It
has been observed in most cancer types and is associated with worse patient outcome. The …

Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …

The mechanisms behind the evolution of complex genomic amplifications in cancer have
remained largely unclear. Using whole-genome sequencing data of the pediatric tumor …

Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA
(ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon …

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …

Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting
genes and regulatory elements can free themselves from chromosomes and relocate to …

Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high
expression of oncogenes through gene amplification and altered gene regulation. Gene …

Focal oncogene amplification and rearrangements drive tumor growth and evolution in
multiple cancer types. We present AmpliconArchitect (AA), a tool to reconstruct the fine …

Examples of extrachromosomal circular DNAs (eccDNAs) are found in many organisms, but
their impact on genetic variation at the genome scale has not been investigated. We …

Numerous studies have shown that non-coding RNAs play crucial roles in the development
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …