HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

M Lechner, J Liu, L Masterson, TR Fenton - Nature reviews Clinical …, 2022 - nature.com
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …

The immune microenvironment in head and neck squamous cell carcinoma: on subsets and subsites

NE Wondergem, IH Nauta, T Muijlwijk… - Current oncology …, 2020 - Springer
Purpose To understand why some patients respond to immunotherapy but many do not, a
clear picture of the tumor microenvironment (TME) of head and neck squamous cell …

Restoring p53 function in head and neck squamous cell carcinoma to improve treatments

T De Bakker, F Journe, G Descamps, S Saussez… - Frontiers in …, 2022 - frontiersin.org
TP53 mutation is one of the most frequent genetic alterations in head and neck squamous
cell carcinoma (HNSCC) and results in an accumulation of p53 protein in tumor cells. This …

Tumor associated macrophage in HPV+ tumors: Between immunosuppression and inflammation

L Gorvel, D Olive - Seminars in immunology, 2023 - Elsevier
Over the past few decades, with the rise of immunotherapies, tumor infiltrating immune cells
were increasingly investigated. Indeed, they may represent biomarkers for patient outcome …

[HTML][HTML] The prognostic role of tumor associated macrophages in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

SK Bisheshar, MF van der Kamp, EJ de Ruiter… - Oral Oncology, 2022 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is an immunogenic cancer type, and
tumor associated macrophages (TAMs) are a major component of the tumor …

HPV involvement in the tumor microenvironment and immune treatment in head and neck squamous cell carcinomas

JR Lechien, G Descamps, I Seminerio, S Furgiuele… - Cancers, 2020 - mdpi.com
Head and neck squamous cell carcinomas (HNSCC) are one of the most prevalent cancers
worldwide. Active human papillomavirus (HPV) infection has been identified as an important …

High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to …

M Toulmonde, C Lucchesi, S Verbeke, A Crombe… - …, 2020 - thelancet.com
Background Undifferentiated pleomorphic sarcoma (UPS) is the most frequent, aggressive
and less-characterized sarcoma subtype. This study aims to assess UPS molecular …

Impact of HPV infection on the immune system in oropharyngeal and non-oropharyngeal squamous cell carcinoma: a systematic review

JR Lechien, I Seminerio, G Descamps, Q Mat… - Cells, 2019 - mdpi.com
Objectives: To review the current knowledge regarding the involvement of human papilloma
virus (HPV) infection and the immune system in the development of head and neck …

Prognostic Significance of the Microenvironment in Human Papillomavirus Oropharyngeal Carcinoma: A Systematic Review

R Baudouin, S Hans, Q Lisan, B Morin… - The …, 2024 - Wiley Online Library
Objective The immune microenvironment of HPV‐associated (HPV+) oropharyngeal
squamous cell carcinomas (OPSCCs)(HPV+ OPSCCs) differs from that of HPV‐independent …

[HTML][HTML] CD163+ cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer

SJ Santegoets, CL Duurland… - … for ImmunoTherapy of …, 2020 - ncbi.nlm.nih.gov
Background Human papillomavirus (HPV)-associated oropharyngeal squamous cell
carcinoma (OPSCC) is a distinct clinical entity with a much better prognosis after (chemo) …