Inhibiting the CDK2/cyclin A2 enzyme has been validated in multiple clinical manifestations
related to multiple types of cancer. Herein, novel series of pyrolo [2, 3-c] pyrazole, pyrolo [2 …

Introduction Abundant evidence suggests that the overexpression of CDK2-cyclin A/E
complex disrupts normal cell cycle regulation, leading to uncontrolled proliferation of cancer …

The development of selective modulators of cyclin-dependent kinases (CDKs), a kinase
family with numerous members and functional variations, is a significant preclinical …

Comparative molecular docking and toxicity between carbon-capped metal oxide nanoparticles
and standard drugs in cancer and bacterial infections - PMC Back to Top Skip to main content …

In the present work, five series of new 2, 3‐disubstituted quinazolin‐4 (3H)‐ones 4a–c, 5a–
d, 6a–g, 7a, b, and 9a–c were designed, synthesized, and screened in vitro for their cytotoxic …

Abstract Compound (E)-N'-(2-bromophenyl)-N-(2, 6-diisopropylphenyl) formamidine (BDF)
was synthesized and elucidated by FT-IR, UV–Visible, 13 C & 1 H-NMR, spectroscopy as …

Current Medicinal Chemistry Page 1 Current Medicinal Chemistry Current Medicinal Chemistry
ISSN: 0929-8673 eISSN: 1875-533X The International Journal for Timely In-depth Reviews in …

Advancements in targeted protein degradation (TPD) technologies are spearheading a new
era in precision oncology, offering unprecedented avenues for tackling key oncogenic …

Novel series of 2-oxindoline hydrazones 6a–h, 3-hydroxy-2-oxoindolines 9a–d and 2-
oxoindolin-3-ylidenes 10a–d were prepared and assessed for their anticancer activity …

Cyclin-dependent kinase 2 (CDK2) is a critical regulator of cell division and has emerged as
a promising target for anticancer treatment. In this article, we summarize the structural …