Programmable and multifunctional DNA‐based materials for biomedical applications

Y Zhang, J Tu, D Wang, H Zhu, SK Maity… - Advanced …, 2018 - Wiley Online Library
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …

Origami and kirigami nanocomposites

L Xu, TC Shyu, NA Kotov - Acs Nano, 2017 - ACS Publications
The arts of origami and kirigami inspired numerous examples of macroscale hierarchical
structures with high degree of reconfigurability and multiple functionalities. Extension of …

An Intelligent DNA Nanorobot with in Vitro Enhanced Protein Lysosomal Degradation of HER2

W Ma, Y Zhan, Y Zhang, X Shao, X Xie, C Mao… - Nano …, 2019 - ACS Publications
DNA nanorobots have emerged as new tools for nanomedicine with the potential to
ameliorate the delivery and anticancer efficacy of various drugs. DNA nanostructures have …

DNA origami nanostructures elicit dose‐dependent immunogenicity and are nontoxic up to high doses In vivo

CR Lucas, PD Halley, AA Chowdury, BK Harrington… - Small, 2022 - Wiley Online Library
DNA origami (DO) nanotechnology enables the construction of precise nanostructures
capable of functionalization with small molecule drugs, nucleic acids, and proteins …

[HTML][HTML] Advances in biological applications of self-assembled DNA tetrahedral nanostructures

S Li, T Tian, T Zhang, X Cai, Y Lin - Materials Today, 2019 - Elsevier
In recent years, there has been a rapid progress in the development of DNA nanomaterials
for biological applications. Owing to their unsurpassed editability, various DNA …

Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation

KA Afonin, MA Dobrovolskaia, W Ke… - Advanced drug delivery …, 2022 - Elsevier
With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now
poised for clinical translation supported by several examples of FDA-approved nucleic acid …

Emerging applications of nanotechnology for controlling cell‐surface receptor clustering

K Zhang, H Gao, R Deng, J Li - … Chemie International Edition, 2019 - Wiley Online Library
The spatial organization of cell‐surface receptors plays an important role in defining cell
fate. Recently, the development of strategies for the direct regulation of receptor clustering …

Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers

S Lauback, KR Mattioli, AE Marras, M Armstrong… - Nature …, 2018 - nature.com
DNA nanotechnology has enabled complex nanodevices, but the ability to directly
manipulate systems with fast response times remains a key challenge. Current methods of …

High-force application by a nanoscale DNA force spectrometer

M Darcy, K Crocker, Y Wang, JV Le… - ACS …, 2022 - ACS Publications
The ability to apply and measure high forces (> 10 pN) on the nanometer scale is critical to
the development of nanomedicine, molecular robotics, and the understanding of biological …

Engineering cell surface function with DNA origami

E Akbari, MY Mollica, CR Lucas… - Advanced …, 2017 - Wiley Online Library
A specific and reversible method is reported to engineer cell‐membrane function by
embedding DNA‐origami nanodevices onto the cell surface. Robust membrane …