This review offers a systematic understanding about how polyphenols target multiple
inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear …

Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

TNFs are major mediators of inflammation and inflammation‐related diseases, hence, the U
nited S tates F ood and D rug A dministration (FDA) has approved the use of blockers of the …

Turmeric, derived from the plant Curcuma longa, is a gold-colored spice commonly used in
the Indian subcontinent, not only for health care but also for the preservation of food and as …

Inflammation is associated with a number of chronic conditions, such as cancer and
cardiovascular disease. Reducing inflammation may help prevent or treat these conditions …

Human tumor necrosis factor (TNF), first isolated by our group as an anticancer agent, has
been now shown to be a primary mediator of inflammation. Till today 19 different members of …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa),
a spice often found in curry powder. Traditionally known for its an antiinflammatory effects …