Ligament and tendon injuries are common problems in orthopedics. There is a need for
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …

Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

Tendon healing follows a complex series of coordinated events, which ultimately produces a
mechanically inferior tissue more scar-like than native tendon. More regenerative healing …

Background Inflammation after tendon-bone junction injury results in the formation of
excessive scar tissue and poor biomechanical properties. Recent research has shown that …

The role of the macrophage is an area of emerging interest in tendinopathy and tendon
healing. The macrophage has been found to play a key role in regulating the healing …

Tendon‐to‐bone interface has a hierarchical structure and gradient component that are
conducive to distributing the stresses to achieve movement. Conventional biomaterials lack …

Tendon adhesion formation describes the development of fibrotic tissue between the tendon
and its surrounding tissues, which commonly occurs as a reaction to injury or surgery. Its …

Adipose‐derived stem cells (ASCs) have the potential to enhance tendon repair via
paracrine regulation of the inflammatory response to injury. Extracellular vesicles (EVs) …

Scarring rather than regeneration, is an inevitable outcome of unbalanced amplifications of
inflammation‐destructive signals and atresia of the regenerative niche. However, identifying …

Adhesion formation during tendon healing remains a severe problem in clinical practice.
Multiple factors contribute to postoperative adhesion formation, and macrophage-driven …