Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Abstract Heme oxygenase-1 (HO-1) is considered to be the main protein in diseases arising
as a result of oxidative and inflammatory insults. Tremendous research has been carried out …

Mycobacterium abscessus complex (MABC) is one of the most clinically relevant species
among nontuberculous mycobacteria. MABC's prevalence has increased over the last two …

Abstract Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO,
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …

Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a
wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Iron metabolism is vital for the survival of both humans and microorganisms. Heme
oxygenase-1 (HO-1) is an essential stress-response enzyme highly expressed in the lungs …

Heme is one of the most abundant molecules in the body acting as the functional core of
hemoglobin/myoglobin involved in the O2/CO2 carrying in the blood and tissues, redox …

Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …

Thalassemia, a chronic disease with chronic anemia, is caused by mutations in the β-globin
gene, leading to reduced levels or complete deficiency of β-globin chain synthesis. Patients …